Micromanipulation is used to interact physically with a sample under a microscope. The need to perform the manipulation of a sample under the microscope has headed to the development of precision micro tools such as cutting tools, injectors, and holding pipettes. Micromanipulation requires the development of a specific micro-tools with the modifications in microscope design. To position micromanipulation equipment, a vibration-free and stable microscope environment is essential for precision work. For the insertion of micromanipulation equipment below the microscope objective, long working distance objectives are required. Micromanipulation is also used in the genetic engineering, semiconductor industry, in vitro fertilization, cell biology and virology. Micromanipulation is most widely used in the fields of electrophysiology, transgenic, IVF, and adherent cell micromanipulation. Micromanipulation is also used in the industrial environments to study colloids and metal particles. Micromanipulation can be done using both upright microscopes and inverted microscopes. There are many instruments used in micromanipulation such as the microinjection systems, micromanipulator, micropipette pullers and bevellers, which allows a lab to produce its own micropipettes. Micromanipulator is a medical device, which is used to manipulate minute specimens and perform complicated procedures using a microscope. Micromanipulators are usually used with a microscope which is equipped with an input joystick. Micromanipulators provide a wide variety of applications ranging from industrial micromanipulation to cell micromanipulation, embracing semiconductors and electronic industries and others.