Sterile sampling systems are used to transfer sample for a defined purpose in aseptic conditions. The purpose of sampling is for batch release testing, in-process control, inspection of substances, deterioration, and adulteration. Sterile Sampling system is used to test verifying the identity, performing complete pharmacopoeial or analogous testing and performing specific tests. The material to be sampled with sterile sampling systems is starting material for use in the manufacture of the finished pharmaceutical product, intermediates in production, pharmaceutical products, etc. Sterile sampling system is designed to prevent contamination, prevention of cross-contamination from other materials, products, and the environment. Sterile sampling is key to cGMP activity that impacts every aspect of the pharmaceutical manufacturing process. Sterile Sampling systems provide additional control for the production environment, product protection, and product handling to ensure the sterility of the product. Air, Equipment sterilization, Personal and materials are usually sampled and monitored. For e.g. Air is tested for both viable (Microorganisms) and Non-viable contaminations in the manufacturing environment. Sampling tools and implements should be made of inert materials and kept aseptically. After use or before usage, they should be thoroughly washed, dried.