Amyloids are the substance made up of abnormally formed protein in the bone marrow that gets saturated in different tissues or organs of the body. The condition is termed as amyloidosis. There are various types of amyloidosis out of which primary systemic amyloidosis are most common, these are associated with plasma cell dyscrasia and has no historical evidence of disease. Kidney, intestines, liver, heart and nerves are the common organs where amyloids get deposited and result in various localized complications. Deposition of amyloids in the heart causes continuous progression towards heart failure by cardiomyopathy, accumulation of amyloids renal system causes renal dysfunction and hepatomegaly can happen because of amyloids infiltration in the liver. Generally diagnosis of this disease is delayed because of no specific symptoms associated with it; however, some symptoms associated with disease include severe fatigue with weakness, feeling of satiety every time, difficulty in swallowing, swelling of tongue. There are several tests used for diagnosis of primary systemic amyloidosis depending on the organ affected, out of which Urinalysis, whole blood count, test for high creatinine level and liver function test are common.