A drive to improve quality, yield, and cycle time coupled with desire for high personal performance has led to novel chemistry methodologies enabling a wide range of reactions in product development. A METTLER TOLEDO white paper explores the interrelationship of two of these critical methodologies, flow chemistry and mid-infrared spectroscopy, in today's highly competitive R&D environment.
Greifensee, Zurich -- (SBWIRE) -- 06/08/2012 -- METTLER TOLEDO is pleased to announce that a new white paper entitled "Enhanced Development and Control of Continuous Processes: A Review of Modern Technologies" is joining the company's extensive collection of thought-leadership resources.
The new paper reviews flow chemistry's revolutionary role in pharmaceutical and fine chemistry environments, including its ability to enhance product quality, increase yield, elucidate synthetic route and improve reaction safety, all while reducing cycle time, which is critical to reducing development costs and capturing market share in today's competitive manufacturing arena.
The paper explores mid-infrared (IR) spectroscopy as a convenient and nondestructive method for real-time inline flow chemistry monitoring, because it allows real-time data-gathering on the formation of products and reactive intermediates. This instantaneous feedback on how changing a parameter such as flow rate or reaction temperature affects a reaction enables faster, safer and more cost-effective process optimization.
The intensity of IR energy absorbed at a particular wavelength is defined by Beer's law to be proportional to concentration, making it possible to track the relative concentration of individual reaction components using mid-IR-enabled technology. Employing this type of technology not only results in improved reaction understanding; it also allows researchers to overcome what used to be significant optimization issues, such as making a controlled addition of reagent stoichiometries to a product stream using output data from a prior reaction stage when performing multi-step synthesis.
The paper describes specific instances where mid-IR technology and flow chemistry principles were applied to monitor product streams/dispersion effects in continuous flow reactors and allowed successful third-stream reagent addition, helping to eliminate poor reaction control and the waste it produces.
For more info: http://www.mt.com/flowchemwp?crel=ePR_PP_EN
Mettler-Toledo International Inc.
Im Langacher, Zip Code 8606,
Phone: +41-44-944 33 85,
About Mettler Toledo
METTLER TOLEDO specializes in the area of precision instruments for professional use. METTLER TOLEDO laboratory instruments are used in research, scientific, drug discovery, and quality control labs, amongst many others in the pharmaceutical, chemical, food and cosmetics industries. METTLER TOLEDO comprehensive industrial solutions cover the various steps in a host of manufacturing processes at many of the same customers that laboratory serves. Solutions range from receiving raw materials through various manufacturing processes, in-line process control and end-of-line packaging control, to logistics and shipping. Increasingly, these solutions are fully integrated into the customer's IT environment, helping automate their workflows. In food retail, our offering for fresh food management ranges from receiving and pre-packaging, to in-store solutions for self-service departments, deli counters, and checkout terminals.