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Competitor Analysis: C-MET/HGF Inhibitors

Posted: Monday, July 22, 2013 at 10:15 AM CDT

Naperville, IL -- (SBWire) -- 07/22/2013 --Reportstack, provider of premium market research reports announces the addition of Competitor Analysis: c-MET/HGF Inhibitors market report to its offering

Competitor Analysis: c-MET/HGF Inhibitors


Product description
The present Competitive Intelligence Report about Competitor Analysis: c-MET/HGF Inhibitors provides a competitor evaluation in the field of small molecule and biologic inhibitors of c-Met (HGF receptor) and its ligand hepatocyte growth factor (HGF) or scatter factor (SF) for the treatment of solid tumors as of July 2013. Purchase of the downloadable pdf report includes a 6-month online access to the data of the report and any updates since the publication date. Credentials to access the database will be sent by e-mail and allow online work with the project data to print or export an individual report.
The c-MET signalling pathway consists of the mesenchymal epithelial transition factor (c-MET) transmembrane tyrosine kinase receptor and its ligand hepatocyte growth factor (HGF) or scatter factor (SF). Binding of HGF/SF to c-MET activates downstream signalling pathways such as Rho, focal adhesion kinase (FAK) and PI3K. These pathways regulate cancer cell growth, survival angiogenesis, invasion and metastasis. Thus, prevention of c-MET dependent neoplastic processes may provide a means for managing invasive tumors of high metastatic potential. In fact, c-MET/HGF has evolved as an attractive target for the pharmaceutical industry.
The report includes a compilation of currently active projects in research and development of small molecule c-Met tyrosine kinase inhibitors, biologic c-MET antagonists and HGF inhibitors in oncology. In addition, the report lists company-specific R&D pipelines of c-MET/HGF inhibitors. Competitor projects are listed in a tabular format providing information on: