Skin substitutes have been used as a form of wound closure since the earliest centuries of medical science. Substitutes are either permanent or temporary depending on their time period. Temporary substitutes are used for a short period to protect the wound area from bacterial contamination and external trauma and to promote easy wound healing.

Pune, India -- (SBWire) -- 03/18/2019 --Skin is the largest organ in the human body and is made up of two main layers, the upper one known as epidermis and the lower one known as dermis. It is in direct contact with the outside world and this makes it most susceptible to injuries or damages. Hence, substitutes are necessary in case of skin wounds and disorders. Skin substitutes have been used as a form of wound closure since the earliest centuries of medical science. Substitutes are either permanent or temporary depending on their time period. Temporary substitutes are used for a short period to protect the wound area from bacterial contamination and external trauma and to promote easy wound healing. On the other hand, permanent skin substitutes are used to replace the full thickness of skin layers and improve the quality of skin at the wound or burn sites permanently. The usage of skin substitutes has shown to accelerate the wound healing thus helping to cope up with the problems of dehydration and infection. As per the American Burn Association (ABA), about 1 million burn injuries occur annually in the United States. This number has increased in the recent years due to which United States has become a prominent market for skin substitutes.

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Skin Substitutes Market is Fragmented Due to the Presence of Many Small and Medium Scale artificial Substitutes Producing Companies

Some of the key participants included in this market:

Stratatech a Mallinckrodt, PolyNovo North America LLC, Organogenesis Inc., Mölnlycke Health Care AB, Medtronic (Covidien), Integra Life Sciences Corporation, Genzyme Corporation, Cook Biotech, Inc., BSN Medical, C. R. Bard, Inc., AMARANTUS BIOSCIENCE HOLDINGS, INC., AlloSource, Advanced Tissue, Acelity L.P. Inc. (KCI- Kinetic Concepts Inc.), Soluble Systems, LLC (Alliqua BioMedical, Inc.), Smith & Nephew plc., Shire Regenerative Medicine, Inc. (formerly Advanced BioHealing, Inc.) and Tissue Regenix Group Plc amongst others. The U.K based pharmaceutical company Mallinckrodt acquired Stratatech corp., in August 2016. to increase its product offering in the skin substitutes market. Stratatech is a privately held regenerative medicine company focused on the development of unique and proprietary skin substitute products.

However, the limitation of the commercially available skin substitutes such as the inability to reproduce skin appendages, lack of capability to replace the lost tissue, particularly the dermis of the skin is preventing the market from growing. Reduced vascularization, scarring, failure to integrate, poor mechanical integrity, and immune rejection are some other limitations. Skin substitutes when placed on wounds need to acquire blood supply promptly for their long-term survival and integration into host tissue. Their inability to re-vascularize rapidly results in cell death and ultimate sloughing away from the host. Although some of the commercially available substitutes undergo angiogenesis, the extent of vascularization offered by them is generally insufficient and has to be improved.

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The Usage of Skin Substitutes in Treatment of Diabetic Foot Ulcers is increasing

Diabetic foot ulcer is a major condition that occurs in people suffering from diabetes mellitus. Treatments of diabetic foot ulcers includes blood sugar control, removal of dead tissue from the wound and wound dressings. Despite the current treatments available for foot ulcers, not all the ulcers can be completely healed by medicines or sugar control and they need a skin substitute for repair of affected area's tissue. Skin substitutes are being used after dead tissue removal from the foot so that the wounds get healed fast.

Biological Skin Substitutes Obtained from Biological Sources is One of The Major Product Type

The biological skin substitutes that mainly include living tissues obtained from biological sources such as plants and animals are being preferred by many due to their intact extracellular matrix structure that allows for effective and scar-free wound healing, which is not provided by any other substitute.

Skin Substitutes Market – By Application
- Burn Injury
- Diabetic Foot Ulcers
- Chronic Wounds
- Others (Vascular Ulcers, Plastic Surgery, Etc.)

Skin Substitutes Market – By Product Type
- Synthetic Skin Substitute
- Biosynthetic Skin Substitute
- Biological Skin Substitute

Market By End User
- Hospitals
- Other Healthcare Facilities

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