Seattle, WA -- (SBWire) -- 09/26/2019 --Natural killer cells play a key role in innate immunity and are considered as a form of granular lymphocytes of various size. They composed of around 10% of total blood lymphocytes as compared to 70% and 20% of T-cells and B cells respectively. As natural killer cells are cytotoxic in nature they can kill their target cells by two different processes such as antibody-dependent cell-mediated cytotoxicity (ADCC) and as the simple natural killer activity of these cells. Furthermore, lectin-like receptors are part of one of two complex membrane receptors family that can identify carbohydrates present on all cells. Such receptors involve their ligands whenever a natural killer cell comes in contact with normal cells, which leads to formation of signal, which in turn stimulates the natural killer cells to carry out its process. Despite the fact, that natural killer cells are demonstrated to be critical components in the early immune responses to a large variety of intracellular pathogens, they are widely used across in clinical application for treating lymphomas and other disorders. Thus, this is expected to fuel growth of the global natural killer cells market over the forecast timeline (2019-2027).

Various studies have been carried to test the vitality of natural killer cells' against infected cells. These studies have been carried out with various intracellular bacteria including as Listeria, Salmonella, and Legionella in humans. The recent study showed exclusive role of killer cells in innate immune repose to microbial pathogens. Moreover, the kill cell can work through different approach of direct recognition of pathogen-derived structures on the surface of infected cells. The immediate response in the clinical abnormalities of natural killer cells is expected to raise the adoption rate, which in turn is projected to promote the growth of the natural killer cells market in the near future.

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Natural Killer Cells Market Taxonomy:
By Product Type
- Kits
- Reagents

By Application
- AIDS
- Malignant and Non-Malignant Cancer
- Immunotherapy
- Stem Cell Transplantation

By End-user
- Clinical Research Institutes
- Cancer Research Institutes
- Research Universities

Rising application of natural killer cells in the treatment of critical disease is presumed to favor the market growth

Natural killer cells play a very crucial role in stem-cell transplantation therapies where it is used for cells activating endogenous natural killer cells and may transfer exogenous cells through adoptive cell therapy (ACT) and hematopoietic stem cell transplantation (HSCT). According to the National Center for Biotechnology Information, U.S. National Library of Medicine, in 2014, such therapies are less effective in eliminating cancer stem cells as revealed by various studies.

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Destructive midline facial lesions have traditionally been referred as lethal midline granuloma. Wegener's granulomatosis, sarcoidosis, conventional Sino-nasal diffuse large B cell, and lymphomas carcinomas are common causative legions in certain patients. However, among patients from Asia and South America, such lesions often show atypical lymphoid cells. This is projected to propel the market growth in the upcoming years. Moreover, pro-inflammatory cytokines are produced by activated natural killer cells, which then trigger Perforin/Granzyme induced target cell lysis. Their specific attaching ability and ability to discard stressed cells are increasing adoption of natural cells therapy, which is expected to support growth of the global natural killer cells market over the forecast period.

Key players engaged in the global natural killer cells market are accelerating their research and development activities to expand their product portfolio. For instance, R&D Systems offer a wide range of reagents for culturing natural killer cells and investigating natural killer cell and tumor cell interactions and various other components such as recombinant proteins, blocking/neutralization antibodies, fluorochrome-conjugated antibodies, and ELISA Kits.

The global natural killer cells market is highly competitive and fragmented, though companies are investing of specific therapy using natural killer cell products to be used in immune-oncology to treat cancer and other tumors. Major players in the market are developing novel products and spending significantly in research and development to expand their product portfolio. Major players in the market of natural killer cells include NantKwest, NKT Therapeutics Inc., AvidBiotics, Glycostem, Sorrento Therapeutics, Inc., CellGenix GmbH, Lonza and R&D Systems, Inc.

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