Cystic Fibrosis Therapeutics Market: Global Industry Analysis, Size, Share, Growth, Trends, and Forecasts 2018–2024
Sarasota, FL -- (SBWIRE) -- 05/17/2018 -- Cystic Fibrosis Therapeutics Market: Overview
Cystic fibrosis is an autosomal recessive and monogenetic disorder as a result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR is a protein (transmembrane) that transports ions across the surface of epithelial cells. CFTR dysfunction affects a number of organs but lung disease is responsible for the majority of mortality in patients with cystic fibrosis.
CF is an autosomal recessive disease as a result of mutations in a gene located on chromosome 7. The CFTR is a single polypeptide protein containing 1480 amino acids that is observed to function both as a cyclic AMP-regulated, Cl- channel and as a regulator of other ion channels. The fully organized form of CFTR is found in the plasma membrane in normal epithelia. In a normal functioning cell, CFTR is synthesized in the rough endoplasmic reticulum (RER) followed by glycosylation in the Golgi apparatus and performing the function of a Cl- channel and regulator of other ion channels when located in the plasma membrane. However, there can be two possible mutations in the CFTR gene, viz., (1) If a mutation disturbs protein folding, CFTR is degraded intracellularly thus, no protein is transported to the plasma membrane. (2) With other mutations, the abnormal protein is processed, reaches to the plasma membrane but functions abnormally at that site.
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Cystic Fibrosis Therapeutics Market: Market Dynamics
The rising prevalence of Cystic Fibrosis (CF) globally, improved diagnostic technologies, growing investment in and awareness about genetic diseases, favorable initiatives undertaken by nonprofit organizations, development of the Healthcare industry and research and development activities undertaken by key players are expected to boost the market over the forecast period.
The market restraints include Cystic Fibrosis Related Complications, Increased Risk of Bacterial Infections in Cystic Fibrosis Patients, high cost involved in treatment and increase in complexity of disease. Observed new opportunities in Cystic Fibrosis Therapeutic market include, patent expiry of many innovator drug companies for Cystic Fibrosis leading to the introduction of generic drugs, Gene Therapy breakthrough for Cystic Fibrosis, better understanding of the genetic structure which would help in innovating new drugs/therapies.
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Segmentation based on Cystic Fibrosis therapeutic drug class:
Based on the therapeutic drug class the segmentation is, Mucolytics, CFTR modulators, Pancreatic enzyme supplements and Bronchodilators.
Segmentation based on Cystic Fibrosis therapeutic route of administration:
Based on the route of drug administration, Oral drugs and Inhaled drugs.
Segmentation based on regions:
North America lead the market for F.Y. 2016; as CF is most prevalent in North America due to the fact that most of the people affected with CF are of Caucasian descent, initiatives taken by Cystic Fibrosis Canada and CF Foundation are one of the key reasons that can be accounted for its largest share. Europe has the second-largest revenue share in global cystic fibrosis therapeutics, followed by markets in Asia Pacific, Latin America, and Middle East & Africa respectively. It is a rapidly growing segment in Asia-Pacific due to rising awareness about CF disorders & various treatment options. In addition, economic development in this region and improving healthcare facilities drive the market in this region.
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Cystic Fibrosis Therapeutics Market: Competitors
Key manufacturers of Cystic Fibrosis Therapeutics include, Hoffmann-La Roche Ltd, Gilead Sciences Inc, Merck & Co Inc, AbbVie Inc, Allergan plc, Alcresta Therapeutics Inc, Novartis AG, Teva Pharmaceutical Industries Ltd, AstraZeneca Plc. among others
Cystic Fibrosis Therapeutics Market: Regional Segment Analysis
The Asia Pacific
The Middle East and Africa
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