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Albany, NY -- (SBWIRE) -- 03/11/2019 -- According to the report, the global humanized mice model market is projected to exhibit a CAGR of 6.0% from 2017 to 2026. In 2017, the market was worth US$ 67.5 Mn and it has been estimated that it will touch a valuation of US$ 113.5 Mn by the end of 2026.
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Humanized mice models have been in use mice for better understanding of the disease, in order to design effective therapies, create accurate models of drug metabolism and improve the understanding of mammalian and human genome function. Market players are incessantly competing for a significant value share and expansion of their global outreach by investing in technologies. With growing need to develop better varieties of humanized mice model and improve the quality and outcome of research studies, the demand for humanized mice models is increasing. However, various technical restrictions may pose as a challenge for the development of the market. Some of the leading companies operating in the market are The Jackson Laboratory, Crown Bioscience Inc. (JSR Life Science), Charles River Laboratories International, Inc., Taconic Biosciences, Inc., Ingenious Targeting Laboratory Inc., Trans Genic Inc., Ltd., GenOway, Creative Animodel, and Horizon Discovery Group plc.
At a commercial level, the market is witnessing various updates, such as emergence of new techniques for customization, alterations of the host to further reduce innate immunity that hampers human cell engraftment, genetic modifications for providing human-specific growth aspects, and cytokines essential for optimal human cell function and growth. There has been a strengthening relationship between drug discovery and development process and the mice models. As a result, the efforts for extemporizing them is also increasing.
Use of humanized mice models will continue to rise in academic and research institutes
Researchers and academicians worldwide are concentrating on the development of innovative vaccines and therapeutics employing humanized mice model, as the data collected from these models is helpful in predicting the clinical outcome of specific drug in development. This is anticipated to trigger the demand for these models in the pharmaceutical industry, CROs as well as academic and research institutes, thus, benefitting the market in turn. Lately in 2018, a team of Yale researchers has developed a new long-acting and less toxic HIV drug that suppresses HIV virus in humanized mice. A parallel study was conducted by researchers at the Temple University and the University of Pittsburgh for removing HIV DNA from the genomes of humanized mice model.
In July 2017, Pharmatest Services had partnered with Taconic Biosciences in a bid to manufacture a new tentative mouse model with a human immune system, precisely made to research bone metastasis. Scientists of the Center for Infectious Disease Research (CIDR) have also discovered an antibody preventing malaria using a unique humanized mouse liver model.
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Adoption of humanized mice models by contract research organizations for clinical research to increase in the coming years
The complete success rate of drugs in the clinical development remains low despite large investments in drug discovery process, predominantly due to inconsistent pre-clinical research. Thereby, humanized mice models are being implemented for bridging the translational gap in the clinical phase. Several research studies have also demonstrated that genetically modified mice are efficient in the documentation of novel gene functions and finding novel drug targets. These models represent influential tools for validating such targets as well as assisting in disease and patient stratification studies. There has been an exponential rise in the employment of mice and other models for translational research and for the in-vivo evaluation of in-vitro selected molecules. Moreover, growing demand for humanized mice model by clinics and laboratories is expected to push the market up in near future.
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