Collagen degradation can be prevented by biomimetic re-mineralization of the stripped collagen fibrils found within the resin-dentine bonding interface on hybrid layers that are not completely permeated.
McAllen, TX -- (SBWIRE) -- 12/19/2014 -- A new study that is considered to be a breakthrough in Minimally Invasive Dentistry has identified a treatment to be relatively useful in reducing the degradation of dentin collagen and the promotion of re-mineralization at the resin-dentine interface as demonstrated by a professor. This is in collaboration with numerous international researchers in a recent dental research report.
According to Salvatore Sauro, a professor at the University CEU Cardenal Herrera in Spain and other researchers who collaborated with the study, zoleodronic acid might be the sole solution to reduce the decline in dentin collagen by host-derived enzymes that many people experience as they age and some with poor oral health as well, as the enhanced re-mineralization processes.
Zoledronic acid is known to be a medication that slows down bone breakdown. As it increases the bone density, it decreases the amount of calcium released by the bone into the blood. This medication is usually given to women who have undergone menopause to treat or prevent osteoporosis, as well as to men.
Aside from osteoporosis, this drug is also administered in treating cancer-related illnesses like Paget's disease or parathyroid diseases wherein calcium is abundant in the blood. Zoledronic acid also known as biphosphonates, is also applied in cancer chemotherapies to cure bone damage inflicted by multiple or by cancer that has begun in another part of the body, but had spread to the bones. Still, the use of Zoledronic acid in chemotherapy will not slow or stop the spread of cancer.
When zoledronic acid that is combined with bioactive resin-based adhesive system was first tested in a restorative dentistry, it showed a very promising result as an innovative strategy that will diminish the deterioration of dentin collagen and will further enhance the re-mineralization. The research performed showed that:
- The re-mineralization properties of bioactive ion-releasing resin-based materials can be raised if these are employed with biomimetic phosphoproteins' analogues of dentine mineralization; and
- The resin-hybridized dentin can be affected by the proteolytic action of host-derived matrix metalloproteinases which is present within the dentine matrix moreover, in the absence of bacterial enzymes.
Yet, collagen degradation can be prevented by biomimetic re-mineralization of the stripped collagen fibrils found within the resin-dentine bonding interface on hybrid layers that are not completely permeated.
For a dentista en McAllen, this advancement in the study on microdentistry is strong evidence that other dental diseases will also be prevented and treated with the help of continuous collaborative works of various dental practitioners and researchers who aim to find a better cure to achieve the overall oral health of people in the coming years.
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