One of the most critical parts in the manufacturing of biopharmaceutical is fill-finish. Any mistakes in this steps will ultimately lead to either contamination, improper packing or mis-formulation. This majorly affects and leads to product failure, safety issues and loss of valuable product. The nature of Fill-Finish operations is largely based on mechanics, involving the manipulation, moving, and packaging of the solid and liquid dosage forms. Several Fill-Finish operations, such as vial filling, are practically unchanged from decades. More or less the liquid dosage forms undergo the same old processes and handling very similar to that of vialed pharmaceuticals. In the same association, Fill-Finish processes of manufacturing have changed relatively in latest years and generally use the most advances methods and equipment. Innovation in this are avoided unless and until necessary.