Panic disorder is an intensive surge of fear and anxiety. It is recurrent, disabling and characterized by its unexpectedness and debilitating, immobilizing intensity. Symptoms include trembling, nausea, shortness of breath, heart palpitations, numbness, and others. Panic disorders may last for 5-10 minutes, but it can linger for hours. If it is left untreated, panic disorders progress to agoraphobia. Panic disorders diagnosed in patients who experience spontaneous attacks and preoccupied with the anxiety of a recurring panic disorder. Panic disorders usually appear in adolescents and rarely observed in children's. Treatment includes psychological therapy, medicinal treatment, anxiety management therapies, and others. In medical treatment, antidepressants and benzodiazepines are used when symptoms are severe. The cause of panic disorders is unclear and is believed that mostly it passes through generations. Etiology of panic disorders can be neurochemical dysfunction of decreased gamma-amino butyric acidergic tone, diminished benzodiazepine receptor function, autonomic imbalance, disturbances in serotonin, and increased adenosine receptor function. Serotonergic model of panic disorders suggests that insufficient or exaggerated receptor response to synaptic serotonin.