Anti-thrombin activators are widely accepted due to their role in reducing thrombus formation. Anticoagulants, anti-platelet drugs, and thrombolytic drugs are some of the different types of anti-thrombin activators available, which act by different mechanisms. While anticoagulants restrict blood clotting, thrombolytic drugs are useful in dissolving clots already formed in the human body. Anti-platelet drugs limit platelets aggregation. Anticoagulants can be further divided into direct factor Xa inhibitors, vitamin K antagonists, direct thrombin inhibitors, and heparin. Some of the thrombolytic therapeutic drugs are tenecteplase, lanoteplase, reteplase, staphylokinase, streptokinase, and urokinase. Various new anti-platelet drugs include adenosine diphosphate receptor (ADP) antagonists, thromboxane A2 receptor antagonists, and protease-activated receptors (PAR-1) antagonists.