Imaging is essential for the detection and monitoring of disease for the treatment. Intra-operative imaging is mainly used during cranial surgeries, as it helps to take images during the surgery without making the patient move, and helps continue with the surgery depending upon the new information. Intra-operative imaging is used to localize and target the diseased tissue and to monitor and control the treatment. Magnetic resonance imaging, ultra-sound based systems, and computed tomography (CT) are mainly used the intra-operative imaging modalities. Intra-operative magnetic resonance imaging is used to create images of the brain during majority of cranial surgeries. It helps create an accurate image of the brain, in order to remove brain tumor and other abnormalities directly, safely, and effectively during the surgery. In addition, it also helps to locate abnormalities if the brain has shifted during the surgery and distinguish abnormal brain tissues from normal brain tissues. It is mainly used during surgery such as brain tumor, dystonia, epilepsy, pituitary tumor, Parkinson's disease, neuropsychiatric disorders, essential tremors, pediatric brain tumor, and glioma. Surgery proceeds in a normal manner with standard instruments and techniques. Intra-operative imaging, during surgery, enables neuro-surgeons to operate more precisely. Moreover, it reduces the need for the patient to undergo a second surgery and also reduces the risk of surgical complication. Sometimes, this technology is also used in combination with neuro-navigation system, to navigate the brain during the surgery, without damaging the vital areas of the brain. In addition, surgical image, with the help of intra-operative imaging devices, has shaped the future of surgical procedure by improving the sensitivity and accuracy of surgeries.