Topical drugs are used for the application where body surfaces such as the skin or mucous membranes to treat ailments. OTC Topical drugs are epicutaneous medication that are applied in the skin directly. The large range of classes included in the topical drugs are creams, foams, gels, lotions and ointments. The advantage of reduced side effects to the other organ. Disadvantage of topical formulation is that it is time consuming, complicated and uncomfortable sometimes. Topical drug formulation are made up in a vehicle or base which is made specific to the site of the body or type of skin. The amount of ingredients observed in the skin totally depends upon type of skin. The different type of formulation of OTC topical drugs includes lotions, creams, ointment, gel, paste etc. Lotions that are usually thicker than a solution and contains oil and water or alcohol. Cream which is thicker than a lotion and usually maintains a shape of 50/50 emulsion of oil and water, it often requires preservatives and maintains the moisture. Ointment is semi-solid, water-free or nearly 80% oil. No need for preservative son contact allergy is rare in case of ointments. Ointments usually contains wool fat, emulsifying wax, macrogols, vegetable oils, beeswax, paraffin etc. Gels are aqueous or alcoholic semisolid emulsion. Paste form of topical drugs are concentrated suspension of oil, water and powder. Aerosol or spray form of topical drug are solutions with pressurized propellant.