Peptic ulcer is a sore or hole in the lining of the stomach, duodenum or esophagus. Peptic ulcer is formed when the lining of the digestive system is corroded by acidic digestive juices. Peptic ulcer is the result of an imbalance between duodenum and digestive fluids in the stomach. Peptic ulcer includes gastric, esophageal and duodenal ulcer. Gastric ulcer occurs inside the stomach whereas esophageal ulcer occurs inside the esophagus that carries food from throat to stomach. Duodenal ulcer occurs inside the upper portion of small intestine. Infections from helicobacter pylori bacteria, uses of nonsteroidal anti-inflammatory drugs, excess acid production from gastrinomas are some of the common causes of peptic ulcer. Stomach pain, bloating, heartburn, nausea and vomiting are some of the common symptoms for peptic ulcer. Bleeding from ulcer is the major symptoms for peptic ulcer. It is identified with the help of bloody and sticky stools. Peptic ulcer can be treated with the help of prescribed and over the counter drugs. Drugs used to treat peptic ulcer are antibiotics, proton pump inhibitors, histamine blocker, antacids and cytoprotective agents. Acid blockers include ranitidine (Zantac), cimetidine (Tagamet), famotidine (Pepcid) and nizatidine (Axid). Cytoprotective medication includes prescription and non-prescription based medications. Prescription based cytoprotective agent includes sucralfate (Carafate) and misoprostol (Cytotec). Non-prescription based cytoprotective agent includes bismuth subsalicylate (Pepto-Bismol). Peptic ulcers that are not healed with medications are known as refractory ulcer. Refractory ulcer usually occurs due to regular use of tobacco, resistance of helicobacter bacteria and regular use of pain relievers. In addition, stomach cancer is another cause for refractory ulcer.