Alpha-amylase is an enzyme, which is used for protein hydrolysis. It is used for hydrolysing the alpha bonds of polymeric carbohydrate molecules i.e. polysaccharide to yield maltose and glucose. Thus, it helps in breakdown of starch and carbohydrates in the body and hence are used as inhibitors for weight loss. Alpha-Amylase is derived from plants, bacteria and fungi. The bacterial and fungal alpha-amylase has dominated in terms of market share and is used in wide range of applications in food and pharmaceutical sector. Solid state and submerged fermentation methods are used in the manufacturing process of alpha-amylase. Submerged fermentation method is the conventional method of alpha-amylase production and the different parameters such as temperature, moisture, pH level etc. can be controlled with ease in this method. Solid state fermentation is expected to account for significant share, due to its resemblance to natural habitat favourable for the growth of microorganisms. Alpha-amylase is used in the production of products such as animal feed, bakery goods, sugar products, brewed products, detergents, biofuels etc. In September 2016, a Denmark-based leading biotechnology company announced acquisition of Organobalance GmbH, a Germany-based research and development company, specialist for manufacturing products based on microbial strain. BASF SE, a Germany-based leading global chemicals manufacturer has acquired Verenium Corporation, a leading manufacturer of performance enhanced enzymes.